| Tobramycin The primary treatment goal is to optimize lung health by controlling bacterial infection (P. aeruginosa)
and mobilizing viscous secretions. The most successful anti-pseudomonal treatment has been tobramycin, which is a more effective aminoglycoside than gentamicin by approximately 50% in vitro. The intravenous (IV) route necessary for tobramycin therapy contributes to the drug's nephrotoxic and ototoxic potential, and requires routine monitoring of serum levels.
Aerosolized tobramycin has proven to be promising for the treatment of P. aeruginosa infections in more stable patients and does not appear to spawn organism resistance. Aerosol routes deliver more medication with less toxicity and provide greater lung access. Aerosol routes are also easier for patient and family because treatments can be taken
at home in lieu of in-patient IV administration.
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